Endocrine Abstracts

Introduction: Inactivating mutations in LH or FSH receptors (R) are known causes of gonadotrophins resistance.Aim: This study aims at evaluating the presence of mutations and polymorphisms of FSHR and LHR and sperm quality in men with hypergonadotropic hypogonadism without obvious testicular noxa.Patients and methods: We selected 8 males with elevated levels of FSH and/or LH and normal levels of testosterone. Sperm parameters were ...

Indoleamine 2,3-dioxygenase 1 (IDO1) is a single chain oxidoreductase that catalyzes tryptophan degradation to kynurenine. In cancer, it appears to exert an immunosuppressive function as part of an acquired mechanism of immune escape. In view of this notion, IDO1 has started to be considered a novel target in cancer therapy. Objective of this study was to evaluate IDO1 expression in papillary thyroid carcinoma (PTC) and to correlate its expression with genetic determinants of ...